drugs should not be taken with cbd

What Drugs Should Not Be Taken With CBD?

CBD is a common medication for chronic pain and gives numerous health benefits that many can attest to. Despite lacking enough studies to prove its advantages, it remains a popular treatment option.

However, the intake of CBD needs careful consideration for those who undergo specific treatment plans for their existing medical condition.

While CBD may be beneficial in reducing specific symptoms, its interaction with other drugs may bring more harm than good to one’s health.

You must know what drugs should not be taken with CBD to avoid additional risks that may be detrimental to your condition.

Why you should be aware of CBD drug interactions?

Cannabidiol, mostly known as CBD, is an active ingredient of the cannabis plant. It is known to produce effects for reducing pain with its positive interaction with the body’s serotonin and cannabinoid receptors.

However, CBD can impact one’s health and bring serious side effects if it interacts with certain drugs.

You must consult with your physician regarding your interest in consuming CBD, especially if you have existing medical conditions that follow strict treatment guidelines.

CBD react with medications

Does CBD react with medications?

CBD is broken down by CYP450, a large family of liver enzymes, just like other medications.

CBD can prevent the enzymes from doing their job if taken in high doses, potentially inhibiting the breakdown of other drugs. As a result, the interaction can increase the side effects of both CBD and certain medications.

Meanwhile, there are instances when CBD induces some enzymes of CYP450, resulting in the quick breakdown of drugs and their reduced effectiveness.

The following are the three main effects of CBD when it interacts with other drugs:

  • Metabolization in the liver. CBD, combined with other drugs, can increase the risk of hepatic impairment and other side effects.
  • Sedative effects. If CBDs are consumed in high doses, it can increase other drugs’ sedative effects, significantly impacting the central nervous system, serotonin receptors, and dopamine receptors. The medicines mainly affecting this phenomenon are barbiturates, opioids, and antidepressants.
  • Anti-inflammatory properties. CBD may suppress the function of the immune system and may prevent other drugs from performing their intended position.

What medications should not be taken with CBD

It is important to note that over 60 percent of prescription drugs undergo breakdown from the same family of enzymes as CBD. This means that most medications may receive impact if taken with CBD. The following medications are some of the most common drugs that may show altered effects due to CBD interaction.
Antiepileptic drugs

Antiepileptic drugs

While some antiepileptic drugs are primarily used along with CBD, certain types show adverse effects with CBD interaction.

Several drugs, including carbamazepine, phenobarbital, and oxcarbazepine, may affect CBD metabolism and its efficacy. Additionally, epileptic medication valproic acid can also result in high levels of enzymes which may lead to liver issues. Potential problems that may occur include live damage and toxicity.


Antidepressants and CBD combinations may lead to overlapping side effects such as sleep disturbances and drowsiness. This can take effect when CBD blocks the enzymes, resulting in decreased liver metabolism.


Benzodiazepines are drugs that can treat anxiety, insomnia, and seizures. However, when combined with CBD, the drug increase blood levels, leading to a higher risk for side effects such as coordination issues and drowsiness.

Opioid analgesics

Opioid analgesics are pain relievers that contain morphine. However, with CBD interaction, the body may have increased blood levels and more significant side effects of morphine. Since opioids and CBD can potentially lower pain issues, it is better to choose only one treatment option at a time to reduce the effects of lethargy, sedation, and fatigue.

Blood thinners

Blood thinners, or anticoagulant drugs, are medications to reduce the alarming signs of heart attack and other heart complications caused by high blood pressure.

With CBD consumption, the effects of blood thinners may be blocked by the compound’s metabolism function in the liver, causing an increased risk of stroke.


CBD interaction with immunosuppressants such as tacrolimus and cyclosporine can cause increased toxicity levels and side effects. With CBD, there is much risk of getting viral infections, including severe conditions such as pneumonia, due to a reduced immune system performance.

Proton pump inhibitors

Proton pump inhibitors are medications that reduce stomach acid production. CBD interaction can cause impact its functions if CBD interferes with the drug’s metabolism. CBD interaction can also potentially lead to side effects like diarrhea.

Certain antimicrobials

Antibiotics can suppress the liver enzymes that break down CBD, significantly impacting CBD side effects. Some antibiotics that you should watch out for are erythromycin and clarithromycin. Antifungals like itraconazole and ketoconazole also affect CBD results.

Blood pressure medications

CBD can lower blood pressure. Thus, if it is combined with other blood pressure drugs like ACE inhibitors, diuretics, and beta blockers, there is an increased risk of very low blood pressure. Other side effects of CBD drug interaction are falls and fainting.
Herbal and dietary supplements

Herbal and dietary supplements

Supplements may affect CBD metabolism and lower blood pressure. Specifically, supplements with ginkgo Biloba may significantly decrease its effects when combined with CBD, which works as a liver enzyme inhibitor.
Who is most at risk for CBD interactions

Who is most at risk for CBD interactions?

Before considering CBD as a treatment option, you need to consult with your healthcare provider about its risk, especially if you fall under any of these risky population:

People with existing medical conditions

If you have other conditions, such as liver disease, you must hold off on CBD consumption. Medical conditions that involve complications in different body organs pose a higher risk of drug interactions and can alter their effects.

Take precautionary measures if you have specific medical conditions and take them to your healthcare provider before taking CBD.

Older adults

The aging population has a higher risk for medical complications such as kidney and liver problems, which require specific medications.

The health of the body organs among adults also starts to decline, which alters the effectiveness of the drugs.

However, if there is CBD, the liver may function abnormally, leading to higher health risks and side effects.

Pregnant or breastfeeding women

CBD use for pregnant and lactating women is highly discouraged. The compound may affect the developing stages of the fetus and the baby and may result in abnormalities.

Does the type of CBD and its dosage make a difference?

Yes, there is a significant difference in the effects of CBD depending on its type, form, and dose.

  • Inhaled CBD. Inhaled CBD works fast, under 30 minutes, and can potentially increase side effects.
  • Edibles. Edibles travel to the bloodstream longer and may need higher concentration to affect one’s blood levels.
  • Topical creams. Topical creams go through the skin before reacting to medications in the bloodstream.
inhaled CBD and topicals

Do inhaled CBD and topicals reduce the risk of drug interactions?

Yes, CBD, taken in different forms, can lower the risk of interactions with other drugs.

Inhaled CBD

Inhalation of CBD travels to the blood quicker and reaches a high concentration within 30 minutes. The side effects of this CBD form are increased. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects.


CBD in topical formulations like lotions and creams can get into the blood more slowly than in other forms, making it an excellent option to delay or block drug interaction. Additionally, the side effects of CBD in topical products have milder effects.

Best CBD oils with minimal drug interaction

CBD oil is a product you can use if you want to enjoy the benefits of CBD without risking drug interaction side effects.

These products can be taken orally, sublingually, or through topical consumption and do not directly merge with drugs for specific medications.

To get the best CBD oil, check out Atmos Smoke for the finest and most trusted products developed by trusted manufacturers.

Call us or visit our shop to get your CBD products today.

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